|
KMID : 0882420100790040381
|
|
Korean Journal of Medicine
2010 Volume.79 No. 4 p.381 ~ p.386
|
|
|
Comparison of the prevalence of insulin resistance between the HCV Antibody positive and non-infected examinee
|
|
Jang Jae-Ho
Kim Hong-Ju
Park Jung-Ho
Park Dong-Il
Cho Yong-Kyun
Son Jung-Il
Jeon Woo-Kyu
Kim Byung-Ik
|
|
|
Abstract
|
|
|
Background/Aims: Considerable evidence indicates that patients with chronic hepatitis C virus (HCV) infection have a greater risk of developing insulin resistance (IR) compared with non-infected individuals or patients with hepatitis B virus (HBV) infection. Few reports have examined the prevalence of IR and hepatic steatosis in patients with chronic HCV infection in Korea.
Methods: Ninety subjects positive for HCV antibody who had normal fasting blood glucose levels and no history of diabetes mellitus were compared with 271 HCV non-infected, age- and sex-matched, healthy examinees between January 2005 and December 2006.
Results: No significant differences in the body mass index (BMI) and fasting blood glucose level were found between the anti-HCV-antibody-positive and non-infected groups. The serum fasting insulin level was significantly higher in the HCV-antibody-positive group than in the non-infected group (9.11±2.94 vs. 8.43±2.70 μU/mL (mean±SD), p=0.04). Although the homeostasis model assessment of insulin resistance (HOMA-IR) was not significantly different between the two groups (2.035±0.69 vs. 1.899±0.64, p=0.088), the prevalence of insulin resistance (HOMA-IR≥2.7) was significantly higher in the anti-HCV positive group (18.9% vs. 10.3%, p=0.042). Hepatic steatosis identified by transabdominal ultrasonography was significantly more frequent in the non-infected group (20.3% vs. 11.1%, p=0.028).
Conclusions: The anti-HCV positive subjects had significant hyperinsulinemia and a higher prevalence of insulin resistance than the non-infected group, whereas hepatic steatosis was more frequent in the non-infected group.
|
|
|
KEYWORD
|
|
|
Insulin resistance, Hepatic steatosis, Chronic hepatitis C, Fasting glucose level, Body mass index
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|